SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
Germany
+49 381 498-7571
olaf.wolkenhauer@uni-rostock.de
Projects
Research Projects
In collaboration with the Division of Gastroenterology at the Rostock University Medical Center (as part of the EnErGie project) we are developing an in-depth, standardized, and computationally encoded disease map of the molecular interactions regulating muscle growth and function. We integrated the two disease states intestinal dysfunctions (ID) and liver cirrhosis (LC) into the map to investigate their contribution to the loss of muscle function (sarcopenia).
The AIR is to provide an interactive platform connecting scientific and medical communities.
Investigating the gut-brain-axis
The gut–brain axis (GBA) provides a bidirectional homeostatic communication between the gastrointestinal tract and the central nervous system. The interdisciplinary collaboration is going to fully explore a first comprehensive GBA cross-disease map of genetic, expression and regulatory changes associated with ulcerative colitis and schizophrenia disease entities.
RNA Sequencing (RNA-Seq) has become a widely used tool to study quantitative and qualitative aspects of the transcriptome. The variety of RNA-Seq protocols, experimental study designs and the characteristic properties of the organisms under investigation greatly affect downstream and comparative analyses. We provide easy access to comprehensive analysis of RNA-Seq experiments as a service. To do so, we leverage on the Galaxy framework, and organise dedicated workshops, training programs, and screencasts to make Life Scientists familiar with computational approaches to biological problems.
Academic background
| 2020 - present |
Research assistant |
| 2018 - 2020 |
M.Sc. in Medical Biotechnology |
| 2014 - 2018 |
B.Sc. in Medical Biotechnology |
Selected publications
Identification of key factors for malnutrition diagnosis in chronic gastrointestinal diseases using machine learning underscores the importance of GLIM criteria as well as additional parameters
In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia
Frontiers in Nutrition (2022)
Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice
Nutrients 2021
The Atlas of Inflammation-Resolution (AIR)
A systems appraoch to investigate inflammation resolution by multicomponent medicinal product TR14
Workflow Development for the Functional Characterization of ncRNAs
Springer (2019), chapter in Computational Biology of Non-Coding RNA. Methods in Molecular Biology, vol 1912.
Machine-Learning-Assisted Construction of a Disease-Specific Molecular Interaction Network from Human Blood RNA-Seq Data
Master thesis within the study degree of Medical Biotechnology
Functional Characterization of Long Non-Coding RNAs from Stem Cell Derived Cardiomyocyte Cell Types
Bachelor thesis within the study degree of Medical Biotechnology