SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
Germany
+49 381 498-7571
olaf.wolkenhauer@uni-rostock.de

Dr. Suchi Smita

To evaluate the toxicity of mixture of chemicals from combustion aerosols, I am developing computational methods that integrate chemometric and multiomics data using structural biology, chemoinformatics and network inference approaches.

Research interest

"I am interested in multi-omics data integration and analysis and my research activities include biological data analysis and interpretation, molecular docking and molecular dynamics simulations along with statistical analysis."

Currently I am working on HICE (Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health) project where multiomics data is being generated from the lung cells exposed to various aerosols from ship diesel and wood combustion. Detail chemometric data is also being generated from the exposure aerosol.

I am specifically working on the biological targets of various chemical entities present in the aerosols. The work involves development of computational methodologies to integrate chemometirc aerosol data with multi-omics exposure data for predicting potential biomarkers for health effects cause by aerosols.

Projects

Research Projects

AIR: Atlas of Inflammation Resolution

The AIR is to provide an interactive platform connecting scientific and medical communities.

2008 - 2012	Ph.D. (Bioinformatics) Thesis title: "Identification of suitable target for GsMTx-4, a Venom peptide from Tarantula for the treatment of High Blood Pressure"
2003 - 2005	M. Sc. (Bioinformatics) Allahabad Agriculture Institute -Deemed University Allahabad, India
2000 - 2003	B.Sc. (Chemistry, Botany, Zoology) Awadh University, Faizabad India
1997 - 2000	Intermediate (Science) Central Board of Secondary Education, New Delhi India
1995 - 1997	High School (Science) Central Board of Secondary Education, New Delhi India

The Atlas of Inflammation-Resolution (AIR)

Serhan CN, Gupta SK, ... , Smita S, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, ... , Wolkenhauer O

Molecular Aspects of Medicine 2020

DOI: https://doi.org/10.1016/j.mam.2020.100894

Pubmed: https://pubmed.ncbi.nlm.nih.gov/32893032/

URL: https://www.sciencedirect.com/science/article/pii/S0098299720300960

Network- and enrichment-based inference of phenotypes and targets from large-scale disease maps

Hoch M, Smita S, Cesnulevicius K, Lescheid D, Schultz M, Wolkenhauer O, Gupta S

npj Systems Biology and Applications (2022)

DOI: 10.1038/s41540-022-00222-z

URL: https://www.nature.com/articles/s41540-022-00222-z

A systems appraoch to investigate inflammation resolution by multicomponent medicinal product TR14

Schopohl P, Smita S, Khan F, Gebhardt T, Hoch M, Brauer D, Cesnulevicius D, Schultz M, Wolkenhauer O, Gupta S

Annals of the Rheumatic Diseases 2019;78:1496.

DOI: http://dx.doi.org/10.1136/annrheumdis-2019-eular.5084

URL: https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1496.1.full.pdf

Deciphering hallmark processes of aging from interaction networks

Smita S, Lange F, Wolkenhauer O, Köhling R

Biochim Biophys Acta. 2016; S0304-4165(16)30264-1.

DOI: https://doi.org/10.1016/j.bbagen.2016.07.017

Computational analysis and modeling the effectiveness of "Zanamivir" targeting neuraminidase protein in pandemic H1N1 strains

Gupta SK, Gupta SK, Smita S, Srivastava M, Lai X, Schmitz U, Rahman Q, Wolkenhauer O, Vera J (2011)

Infection, Genetics and Evolution 11: 1072 - 1082

DOI: https://doi.org/10.1016/j.meegid.2011.03.018

URL: http://www.sciencedirect.com/science/article/pii/S1567134811000992

Identification of immunogenic consensus T-cell epitopes in globally distributed influenza-A H1N1 neuraminidase

Gupta SK, Srivastava M, Akhoon BA, Smita S, Schmitz U, Wolkenhauer O, Vera J, Gupta SK (2011)

Infection, Genetics and Evolution 11: 308 - 319

DOI: https://doi.org/10.1016/j.meegid.2010.10.013

Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/21094280

URL: http://www.sciencedirect.com/science/article/pii/S1567134810002947

Geraniol and limonene interaction with 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase for their role as cancer chemo-preventive agents

Pattanayak M, Seth PK, Smita S, Gupta SK (2009)

Journal of Proteomics & Bioinformatics 2: 466-474

DOI: 10.4172/jpb.1000107

URL: https://www.omicsonline.org/hmg-coa-reductase-for-their-role-as-cancer-chemo-preventive-agents-jpb.1000107.php?aid=1410

Mechanistic Understanding of Inflammation Resolution Using the Atlas of Inflammation Resolution (AIR)

Müller RLJ, Cavallo C, Gupta SS, Hoch M, Gupta S

In: Tripathi, A., Dwivedi, A., Gupta, S., Poojan, S. (eds) Inflammation Resolution and Chronic Diseases. Springer, Singapore.

ISBN 13 (print): 978-981-97-0156-8

ISBN 13 (online): 978-981-97-0157-5

DOI: https://doi.org/10.1007/978-981-97-0157-5_13

URL: https://link.springer.com/chapter/10.1007/978-981-97-0157-5_13

Enriching biotechnology with recent bioinformatics tools and protocols

Gupta SK, Smita S, Rahman Q

in: Recent trends in Biotechnology; Singh MP, Agrawal A, Sharma B (eds.); Nova Science Publishers Inc. 2011.

ISBN 13 (print): 9781608761487

Education and Work Experience

Wissenschaftliche Mitarbeiterin in Comprehensive Molecular Analytics, Helmholtz Zentrum München
Post-doctoral Fellow Oscar Langendorff Institute für Physiologie der Universitätsmedizin, Rostock
Post-doctoral Fellow at Department of Systems Biology and Bioinformatics, Rostock, Germany

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