LOgo SBI Uni Rostock

SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
Germany
  +49 381 498-7571
  olaf.wolkenhauer@uni-rostock.de

Dr. Xin Lai

I am focusing on microRNAs research, where I am applying the systems biology approach to uncover its function in cellular signalling pathway.

Research interest

Small microRNAs play big roles

"I am focusing on microRNAs research, where I am applying the systems biology approach to uncover its function in cellular signalling pathway."

My research focuses on building and analyzing mathematical models that describe problems in finding the links between cancer and aging. Areas of particular interest include signalling pathway related to cancer caused by the deregulation of p53 and the regulatory dynamics of miRNAs. The mathematical tools that I use include nonlinear dynamics, sensitivity and bifurcation analysis, optimization methods and multiscale-hybrid modeling.

Curriculum Vitae

Academic background

2008 - 2012

Dr.-Ing. in Systems Biology and Bioinformatics
University of Rostock, Rostock/Germany
2005 - 2008

M.S. in Computational Engineering
University of Rostock, Rostock/Germany
2001 - 2005

B.S. in Computer Science
Chengdu University of Technology, Chengdu/China

Selected publications

MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance.

Lai X, Gupta SK, Schmitz U, Marquardt S, Knoll S, Spitschak A, Wolkenhauer O, Pützer BM, Vera J

Theranostics. 2018 Jan 1;8(4):1106-1120.

DOI: https://doi.org/10.7150/thno.19904

Pubmed: 29464002

URL: http://www.thno.org/v08p1106.htm

A systems biology approach to study microRNA-mediated gene regulatory networks (2013)

Lai X, Bhattacharya A, Schmitz U, Kunz M, Vera J, Wolkenhauer O

BioMed Research International, vol. 2013,

DOI: http://dx.doi.org/10.1155/2013/703849

Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network

Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Pützer BM (2013)

Cancer Research,

DOI: http://dx.doi.org/10.1158/0008-5472.CAN-12-4095

URL: http://cancerres.aacrjournals.org/content/early/2013/02/27/0008-5472.CAN-12-4095.abstract

Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs

Lai X, Schmitz U, Gupta S, Bhattacharya A, Kunz M, Wolkenhauer O, Vera J (2012)

Nucleic Acids Research, 40: 8818-8834.

DOI: https://doi.org/10.1093/nar/gks657

URL: http://nar.oxfordjournals.org/content/early/2012/07/13/nar.gks657.abstract

Model-based investigation of the transcriptional activity of p53 and its feedback loop regulation via 14-3-3Σ

Vera J, Nikolov S, Lai X, Singh A, Wolkenhauer O (2011)

IET Systems Biology 5: 293-307

DOI: http://dx.doi.org/10.1049/iet-syb.2010.0080

URL: http://digital-library.theiet.org/content/journals/10.1049/iet-syb.2010.0080

Integration of sensitivity and bifurcation analysis to detect critical processes in a model combining signalling and cell population dynamics

Nikolov S, Lai X, Liebal UW, Wolkenhauer O, Vera J (2010)

International Journal of Systems Science 41: 81-105

DOI: https://doi.org/10.1080/00207720903147746

URL: http://www.informaworld.com/10.1080/00207720903147746

A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis

Lai X, Nikolov S, Wolkenhauer O, Vera J (2009)

Computational Biology and Chemistry 4: 312-324

DOI: https://doi.org/10.1016/j.compbiolchem.2009.07.003

URL: http://www.sciencedirect.com/science/article/B73G2-4WR19X1-1/2/92f6a7ed0e4bb0ef665677b0e099998b

Time delay and protein modulation analysis in a model of RNA silencing

Nikolov S, Lai X, Wolkenhauer O, Vera J (2009)

Communications of SIWN 6: 111-117

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Time delay and Epo dose modulation in a multilevel model for erythropoiesis

Nikolov S, Lai X, Wolkenhauer O, Vera J (2009)

Bioautomation 12: 53-69

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Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

Eberhardt M, Lai X, Tomar N, Gupta SK, Schmech B, Steinkasserer A, Schuler G, Vera J

In: Systems Medicine, Methods in Molecular Biology (2016) 1386: 135-179.
Published by Springer.

ISBN 13 (print): 9781493932825

Modelling miRNA regulation in cancer signalling systems: miR-34a regulation of the p53/Sirt1 signalling module

Lai X, Wolkenhauer O, Vera J

in: Computational Modelling of Signalling Networks; Liu X, Betterton M (eds.); Humana 2012.

ISBN 13 (print): 9781617798230

Predicting targets of synergistic microRNA regulation

Schmitz U, Gupta S, Lai X, Vera J, Wolkenhauer O

German Conference on Bioinformatics 2013, Göttingen, Germany

Venue: Göttingen, Germany

A systems biology approach to study the cellular function of microRNAs

Lai X, Schmitz U, Vera J, Wolkenhauer O

International Workshop on Small RNA in Cancer, Inflammation, and Aging, Copenhagen, Denmark, September 3 - 4, 2012.

Venue: Copenhagen, Denmark

The role of micro RNA regulation in the early inflammatory response: miR-146a and NFkB signaling in lung inflammation

Lai X, Schulz C, Dolniak B, Wolkenhauer O, Schmeck B, Vera J, Sittka A

Symposium on Remodeling, Repair and Regeneration in Lung Diseases, Marburg, Germany, June 21-23, 2012
Best poster award

Venue: Marburg, Germany

On the regulation of microRNA target hubs: a Systems Biology perspective

Lai X, Schmitz U, Gupta S, Kunz M, Wolkenhauer O, Vera J

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

The role of micro RNA regulation in the early inflammatory response: miR-146a and NFkB signaling in lung inflammation

Lai X, Schulz C, Sittka A, Dolniak B, Wolkenhauer O, Schmeck B and Vera J

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Modeling miRNA regulation in signaling networks: miR-34a regulation of p53/Sirt1 module

Lai X, Vera J, Wolkenhauer O

Conference on Systems Biology of Mammalian Cells-SBMC2010, Freiburg, Germany, 3-5 June 2010

Venue: Freiburg, Germany

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Lao A, Schmidt V, Rateitschak K, Wolkenhauer O, Willnow T

Mid-term review of the Helmholtz Alliance on Systems Biology, DKFZ, Heidelberg, Germany, 13.01.-14.01.2010

Venue: Heidelberg, Germany

A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis

Lai X, Nikolov S, Wolkenhauer O, Vera J

The 2009 International Workshop on "Computational and Integrative Biology" (CIB 2009), Hangzhou, China, 18.09.-20.09.2009

Venue: Hangzhou, China

Use of sensitivity analysis to detect critical biochemical processes in a mathematical model linking intracellular and cell population dynamics in erythropoiesis

Lai X, Liebal U, Nikolov S, Wolkenhauer O, Vera J

The 6th Conference on Computational Methods in Systems Biology (CMSB), Rostock-Warnemünde, Germany, October 2008

Venue: Rostock-Warnemünde, Germany

Downloads & more:

A systems biology approach to unravel the cellular function of microRNAs

Lai X

2012

Mathematical modelling and mathematical optimisation of biochemical systems: a method of analysis in biotechnology and biomedicine

Lai X

2007

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