SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
Germany
+49 381 498-7571
olaf.wolkenhauer@uni-rostock.de

Sherry Freiesleben

To uncover aberrant molecular mechanisms behind diseases such as multiple sclerosis or radiation sickness, I study gene expression, transcription factors, microRNAs and lncRNAs to construct regulatory networks which I then explore

Research interest

microRNAs and data integration - Why should we even bother?

microRNAs (miRNAs) are non-coding RNAs that post-transcriptionally regulate gene expression. They partake in diverse biological processes and have been reported to be involved in many diseases. Their expression profiles can easily be investigated since they are present in a stable form in human blood and plasma.

Therefore, what role do these tiny molecules play in the development of diseases?

To answer this question, I first analyze transcriptomics data in order to identify candidate miRNAs and genes. I then make use of data originating from various databases and of data integration methods to generate regulatory networks. After constructing these networks, I apply network analysis methods such as to uncover regulatory interactions involving miRNAs which may help us better understand the role of these molecules in diseases.

Academic background

2011 -present	PhD: Bioinformatics University of Rostock, Rostock, Germany
2009 - 2011	Master of Science: Medical Biotechnology University of Rostock, Rostock, Germany
2009 - 2006	Bachelor of Science: Major Physiology, Minor Physics McGill University, Montreal, Canada
Summer Semester 2006	Guest Student: Physics University of Rostock, Rostock, Germany
2003 - 2005	Diploma of College Studies: Health Science Vanier College, Montreal, Canada

A workflow for the creation of regulatory networks integrating miRNAs and lncRNAs associated with exposure to ionizing radiation using open source data and tools

Freiesleben S, Unverricht-Yeboah M, Gütebier L, Waltemath D, Kriehuber R, Wolkenhauer O

accepted for publication in Frontiers in Systems Biology

Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study.

Singh N, Freiesleben S, Wolkenhauer O, Shukla Y, Gupta SK

Curr Pharm Des. 2017;23(32):4773-4793.

DOI: https://doi.org/10.2174/1381612823666170710152918

Pubmed: 28699531

URL: http://www.eurekaselect.com/154061

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

Sherry Freiesleben, Michael Hecker, Uwe Klaus Zettl, Georg Fuellen, Leila Taher

Scientific Reports (2016) 6: 34512

DOI: https://doi.org/10.1038/srep34512